Activation of Tyk2 and Stat3 is required for the Apoptotic Actions of IFNβ in Primary Pro-B cells

Activation of Tyk2 and Stat3 is required for the Apoptotic Actions of IFNβ in Primary Pro-B cells. Ana M. Gamero, Ramesh Potla, Joanna Wegrzyn, Magdelena Szelag, Andrea E. Edling, Kazuya Shimoda, Daniel C. Link, Jozef Dulak, Darren P. Baker, Yoshinari Tanabe, Jason M. Grayson, and Andrew C. Larner 1 Laboratory of Experimental Immunology, National Cancer Institute-Frederick, MD 21702; Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; 3 Medicine and Biosystemic Science, Kyushu University Fukuoka, Japan; 4 Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110; 5 Department of Cell Biochemistry, Faculty of Biotechnology, Jagiellonian University, Krakow, Poland; 6 Department of Biology, Cleveland State University, Cleveland, OH 44195; Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142; 8 Department of Microbiology and Immunology, Wake Forest University School of Medicine, 5100A Gray Building, Winston-Salem, NC 27157; 9 Department of Medicine, Niigata University School of Medicine Niigata, Japan; Running Title: Role for Stat3 activation in IFNβ stimulated apoptosis Address correspondence to: Andrew C. Larner, Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; Tel. (216) 445-9045; Fax: (216) 444-8372; Email: [email protected]